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Volume 23 , Issue 1
January/February 2003
Pages 9–17

Evaluation of Periodontal Regeneration Following Grafting Intrabony Defects with Bio-Oss Collagen: A Human Histologic Report

Marc L. Nevins, DDS, MMSc, Marcelo Camelo, Samuel E. Lynch, DMD, DMSc, Robert K. Schenk, MD, Prof Dr Med, Myron Nevins, DDS

PMID: 12617364
DOI: 10.11607/prd.00.0507

This study evaluated the clinical, radiographic, and histologic response to Bio-Oss Collagen when used alone or in combination with Bio-Gide bilayer collagen membrane for the treatment of four intrabony defects (5 to 7 mm) around single-rooted teeth. After reflecting a full-thickness flap, thorough degranulation and root planing were accomplished. In all cases, Bio-Oss Collagen was then used to fill the defects, and in two cases, a Bio-Gide membrane was placed over the filled defect. Radiographs, clinical probing depths, and attachment levels were obtained before treatment and immediately preceding en bloc resection of teeth and surrounding tissues 9 months later. Reduction in pocket depth and gain in clinical attachment level were observed for both treatment protocols. The histologic evaluation demonstrated the formation of a complete new attachment apparatus, evidencing periodontal regeneration that varied with defect morphology. This human histologic study demonstrated that Bio-Oss Collagen has the capacity to induce regeneration of the periodontal attachment apparatus when placed in intrabony defects. (Int J Periodontics Restorative Dent 2003;23:9–17.)

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